MC-EVCit-PAB-MMAE
MC-EVCit-PAB-MMAE (Linker-Payload 11) is a drug-linker conjugates for ADC. MC-EVCit-PAB-MMAE contains the ADCs linker (MC-EVCit-PAB) and a potent tubulin polymerization inhibitor MMAE.
Product Specifications
CAS Number
2873452-49-2
UNSPSC
12352203
Target
Drug-Linker Conjugates for ADC; Microtubule/Tubulin
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mc-evcit-pab-mmae.html
Purity
99.04
Solubility
DMSO : 85 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC([C@H](CCC(O)=O)NC(CCCCCN4C(C=CC4=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)OC)=O
Molecular Formula
C73H112N12O18
Molecular Weight
1445.74
References & Citations
[1]Matsuda, Yutaka, et al. Conjugate of antibody and functional substance or salt of said conjugate, and compound for use in production of said conjugate or salt of said compound. Patent. WO2022255425.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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