Ercalcitriol

Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a vitamin D receptor (VDR) agonist with high binding affinity. After binding to VDR, Ercalcitriol forms a complex with retinoid X receptor (RXR) to regulate target gene transcription. For example, Ercalcitriol induces human gingival/oral epithelial cells to produce human cat antimicrobial peptide (hCAP-18/LL-37), which has antimicrobial activity against periodontal pathogens such as Porphyromonas gingivalis. Ercalcitriol enhances the innate immune defense of the oral mucosa by promoting the expression of antimicrobial peptides, and is mainly used in the study of periodontal diseases and immune-related oral diseases[1][2].

Product Specifications

CAS Number

[60133-18-8]

Product Name Alternative

1α,25-Dihydroxy Vitamin D2

UNSPSC

12352211

Hazard Statement

H301+H311, H330, H372

Target

Drug Metabolite; Endogenous Metabolite; VD/VDR

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Ercalcitriol.html

Purity

99.42

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C=C1[C@H](C[C@@H](C/C1=C/C=C2[C@]3([C@@](C)([C@H](CC3)[C@@H](/C=C/[C@@H](C(C)(O)C)C)C)CCC/2)[H])O)O

Molecular Formula

C28H44O3

Molecular Weight

428.65

Precautions

H301+H311, H330, H372

References & Citations

[1]Mawer EB, et al. A sensitive radioimmunoassay using a monoclonal antibody that is equipotent for ercalcitriol and calcitriol (1,25-dihydroxy vitamin D2 and D3) .Clin Chim Acta. 1990 Oct 15;190 (3) :199-209.|[2]Tada H, et al. Vitamin D3 analog maxacalcitol (OCT) induces hCAP-18/LL-37 production in human oral epithelial cells. Biomed Res. 2016;37 (3) :199-205.