EN106
Product Specifications
UNSPSC Description
EN106 is a potent inhibitor of FEMIB. EN106 is a cysteine-reactive covalent ligand. EN106 disrupts recognition of the key reductive stress substrate of FEM1B, FNIP1[1].
Target Antigen
E1/E2/E3 Enzyme
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/en106.html
Purity
99.85
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(N(CCC#N)C1=CC=C(OCCO2)C2=C1)CCl
Molecular Weight
280.711
References & Citations
[1]Henning NJ, et al. Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications. J Am Chem Soc. 2022;144(2):701-708.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-W229874/EN106-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-W229874/EN106-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
757192-67-9
Available Sizes
Curated Selection
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