CYP1B1-IN-8
CYP1B1-IN-8 (Compound 14b) is a CYP1B1 inhibitor (IC50: 4.14 x 10–5 nM). CYP1B1-IN-8 reduces the resistance in A549 cells to Paclitaxel , and inhibits cell migration and invasion[1].
Product Specifications
UNSPSC
12352005
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cyp1b1-in-8.html
Solubility
10 mM in DMSO
Smiles
IC1=CC=C(C2=NC3=CC=CC=C3C(NCC)=N2)C=C1.Cl
Molecular Formula
C16H15ClIN3
Molecular Weight
411.67
References & Citations
[1]Yang M, et al. Design of Novel 2-Phenylquinazolin-4-amines as Selective CYP1B1 Inhibitors for Overcoming Paclitaxel Resistance in A549 Cells. J Med Chem. 2024 Apr 11;67 (7) :5883-5901.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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