Nafoxidine (hydrochloride)

Nafoxidine hydrochloride is a non-steroidal estrogen receptor antagonist with antitumor activity for breast cancer[1][2][3].

Product Specifications

CAS Number

[1847-63-8]

Product Name Alternative

Nafoxidene (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302+H312-H351

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nafoxidine-hydrochloride.html

Smiles

[H]Cl.COC1=CC2=C(C=C1)C(C3=CC=C(C=C3)OCCN4CCCC4)=C(C5=CC=CC=C5)CC2

Molecular Formula

C29H32ClNO2

Molecular Weight

462.02

Precautions

P264-P270-P280-P302+P352-P330-P362+P364-P405-P501

References & Citations

[1]Sato M, Rippy MK, Bryant HU. Raloxifene, tamoxifen, nafoxidine, or estrogen effects on reproductive and nonreproductive tissues in ovariectomized rats. FASEB J. 1996;10 (8) :905-912.|[2]De Lorenzo MS, Farina HG, Alonso DF, Gomez DE. Role of protein kinase C-dependent signaling pathways in the antiangiogenic properties of nafoxidine. Anticancer Res. 2004;24 (3a) :1737-1743.|[3]Yaz G, Kabadere S, Oztopçu P, Durmaz R, Uyar R. Comparison of the antiproliferative properties of antiestrogenic drugs (nafoxidine and clomiphene) on glioma cells in vitro. Am J Clin Oncol. 2004;27 (4) :384-388.