Nemiralisib
Nemiralisib (GSK2269557 free base) is a potent and highly selective PI3Kδ inhibitor with a pKi of 9.9.
Product Specifications
CAS Number
[1254036-71-9]
Product Name Alternative
GSK2269557 (free base)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/GSK2269557-free-base.html
Purity
99.80
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
CC(N1CCN(CC2=CN=C(C3=CC(C4=CC=CC5=C4C=CN5)=CC6=C3C=NN6)O2)CC1)C
Molecular Formula
C26H28N6O
Molecular Weight
440.54
Precautions
H302, H315, H319, H335
References & Citations
[1]Down K et al. Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase δ for the Treatment of Respiratory Disease.
 J Med Chem. 2015 Sep 24;58 (18) :7381-99.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
Available Sizes
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