Nemiralisib

Nemiralisib (GSK2269557 free base) is a potent and highly selective PI3Kδ inhibitor with a pKi of 9.9.

Product Specifications

CAS Number

[1254036-71-9]

Product Name Alternative

GSK2269557 (free base)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/GSK2269557-free-base.html

Purity

99.80

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

CC(N1CCN(CC2=CN=C(C3=CC(C4=CC=CC5=C4C=CN5)=CC6=C3C=NN6)O2)CC1)C

Molecular Formula

C26H28N6O

Molecular Weight

440.54

Precautions

H302, H315, H319, H335

References & Citations

[1]Down K et al. Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase δ for the Treatment of Respiratory Disease. J Med Chem. 2015 Sep 24;58 (18) :7381-99.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Isoform

PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ

Available Sizes

Curated Selection

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