Nemiralisib
Product Specifications
UNSPSC Description
Nemiralisib (GSK2269557 free base) is a potent and highly selective PI3Kδ inhibitor with a pKi of 9.9.
Target Antigen
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/GSK2269557-free-base.html
Purity
99.80
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
CC(N1CCN(CC2=CN=C(C3=CC(C4=CC=CC5=C4C=CN5)=CC6=C3C=NN6)O2)CC1)C
Molecular Weight
440.54
References & Citations
[1]Down K et al. Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase δ for the Treatment of Respiratory Disease.
J Med Chem. 2015 Sep 24;58(18):7381-99.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-19535A/Nemiralisib-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-19535A/Nemiralisib-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
1254036-71-9
Available Sizes
Curated Selection
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