NSC 74859

NSC 74859 (S3I-201) is a selective Stat3 inhibitor with an IC50 of 86 μM[1].

Product Specifications

CAS Number

[501919-59-1]

Product Name Alternative

S3I-201

UNSPSC

12352005

Hazard Statement

H302

Target

STAT

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/NSC-74859.html

Purity

98.35

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC(NC(COS(=O)(C2=CC=C(C=C2)C)=O)=O)=CC=C1C(O)=O

Molecular Formula

C16H15NO7S

Molecular Weight

365.36

Precautions

H302

References & Citations

[1]Siddiquee K, et al. Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc Natl Acad Sci U S A. 2007 May 1;104 (18) :7391-6.|[2]Lin L, et al. The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-β signaling. Oncogene. 2009 Feb 19;28 (7) :961-72.|[3]Zhou C, et al. STAT3 upregulation in pituitary somatotroph adenomas induces hypersecretion. J Clin Invest. 2015 Apr;125 (4) :1692-702