NSC 74859
NSC 74859 (S3I-201) is a selective Stat3 inhibitor with an IC50 of 86 μM[1].
Product Specifications
CAS Number
501919-59-1
Product Name Alternative
S3I-201
UNSPSC
12352005
Hazard Statement
H302
Target
STAT
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/NSC-74859.html
Purity
98.35
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=CC(NC(COS(=O)(C2=CC=C(C=C2)C)=O)=O)=CC=C1C(O)=O
Molecular Formula
C16H15NO7S
Molecular Weight
365.36
Precautions
H302
References & Citations
[1]Siddiquee K, et al. Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc Natl Acad Sci U S A. 2007 May 1;104 (18) :7391-6.|[2]Lin L, et al. The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-β signaling. Oncogene. 2009 Feb 19;28 (7) :961-72.|[3]Zhou C, et al. STAT3 upregulation in pituitary somatotroph adenomas induces hypersecretion. J Clin Invest. 2015 Apr;125 (4) :1692-702
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT3
Available Sizes
Frequently Asked Questions
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