11-Ketodihydrotestosterone

11-Ketodihydrotestosterone (11-KDHT; 5α-Dihydro-11-keto testosterone) is an endogenous steroid and a metabolite of 11β-Hydroxyandrostenedione. 11-Ketodihydrotestosterone is an active androgen and is also a potent androgen receptor (AR) agonist with a Ki of 20.4 nM and an EC50 of 1.35 nM for human AR. 11-Ketodihydrotestosterone drives gene regulation, protein expression and cell growth in androgen-dependent prostate cancer cells[1][2].

Product Specifications

CAS Number

[32694-37-4]

Product Name Alternative

11-KDHT; 5α-Dihydro-11-keto testosterone

UNSPSC

12352211

Target

Androgen Receptor

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/11-ketodihydrotestosterone.html

Concentration

10mM

Purity

99.8700

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@]1(C2)[C@@H](O)CC[C@@]1([H])[C@]3([H])CC[C@@]4([H])CC(CC[C@]4(C)[C@@]3([H])C2=O)=O

Molecular Formula

C19H28O3

Molecular Weight

304.42

References & Citations

[1]Pretorius E, et al. 1-Ketotestosterone and 11-Ketodihydrotestosterone in Castration Resistant Prostate Cancer: Potent Androgens Which Can No Longer Be Ignored. PLoS One. 2016 Jul 21;11 (7) :e0159867.|[2]du Toit T, et al. Profiling adrenal 11β-hydroxyandrostenedione metabolites in prostate cancer cells, tissue and plasma: UPC2-MS/MS quantification of 11β-hydroxytestosterone, 11keto-testosterone and 11keto-dihydrotestosterone. J Steroid Biochem Mol Biol. 2017 Feb;166:54-67.