Pyrvinium pamoate
Pyrvinium pamoate is an FDA-approved antihelmintic agent that inhibits WNT pathway signaling.
Product Specifications
CAS Number
3546-41-6
Product Name Alternative
Pyrvinium embonate
UNSPSC
12352005
Hazard Statement
H302+H312+H332, H315, H319, H335, H351
Target
Wnt
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Pyrvinium_pamoate.html
Purity
99.75
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
C[N+]1=C2C=CC(N(C)C)=CC2=CC=C1/C=C/C3=C(C)N(C4=CC=CC=C4)C(C)=C3.C[N+]5=C6C=CC(N(C)C)=CC6=CC=C5/C=C/C7=C(C)N(C8=CC=CC=C8)C(C)=C7.O=C(C9=C(O)C(CC%10=C%11C=CC=CC%11=CC(C([O-])=O)=C%10O)=C%12C=CC=CC%12=C9)[O-]
Molecular Formula
C26H28N3.1/2C23H14O6
Molecular Weight
575.70
Precautions
H302+H312+H332, H315, H319, H335, H351
References & Citations
[1]Xu L, et al. WNT pathway inhibitor pyrvinium pamoate inhibits the self-renewal and metastasis of breast cancer stem cells. Int J Oncol. 2016 Mar;48 (3) :1175-86.|[2]Wiegering A, et al. The impact of pyrvinium pamoate on colon cancer cell viability. Int J Colorectal Dis. 2014 Oct;29 (10) :1189-98.|[3]Venerando A, et al. Pyrvinium pamoate does not activate protein kinase CK1, but promotes Akt/PKB down-regulation and GSK3 activation. Biochem J. 2013 May 15;452 (1) :131-7.|[4]Murakoshi M, et al. An anthelmintic drug, pyrvinium pamoate, thwarts fibrosis and ameliorates myocardial contractile dysfunction in a mouse model of myocardial infarction. PLoS One. 2013 Nov 4;8 (11) :e79374.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
Frequently Asked Questions
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