Pyrvinium pamoate

Pyrvinium pamoate is an FDA-approved antihelmintic agent that inhibits WNT pathway signaling.

Product Specifications

CAS Number

[3546-41-6]

Product Name Alternative

Pyrvinium embonate

UNSPSC

12352005

Hazard Statement

H302+H312+H332, H315, H319, H335, H351

Target

Wnt

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Pyrvinium_pamoate.html

Purity

99.75

Solubility

DMSO : 16.67 mg/mL (ultrasonic)

Smiles

C[N+]1=C2C=CC(N(C)C)=CC2=CC=C1/C=C/C3=C(C)N(C4=CC=CC=C4)C(C)=C3.C[N+]5=C6C=CC(N(C)C)=CC6=CC=C5/C=C/C7=C(C)N(C8=CC=CC=C8)C(C)=C7.O=C(C9=C(O)C(CC%10=C%11C=CC=CC%11=CC(C([O-])=O)=C%10O)=C%12C=CC=CC%12=C9)[O-]

Molecular Formula

C26H28N3.1/2C23H14O6

Molecular Weight

575.70

Precautions

H302+H312+H332, H315, H319, H335, H351

References & Citations

[1]Xu L, et al. WNT pathway inhibitor pyrvinium pamoate inhibits the self-renewal and metastasis of breast cancer stem cells. Int J Oncol. 2016 Mar;48 (3) :1175-86.|[2]Wiegering A, et al. The impact of pyrvinium pamoate on colon cancer cell viability. Int J Colorectal Dis. 2014 Oct;29 (10) :1189-98.|[3]Venerando A, et al. Pyrvinium pamoate does not activate protein kinase CK1, but promotes Akt/PKB down-regulation and GSK3 activation. Biochem J. 2013 May 15;452 (1) :131-7.|[4]Murakoshi M, et al. An anthelmintic drug, pyrvinium pamoate, thwarts fibrosis and ameliorates myocardial contractile dysfunction in a mouse model of myocardial infarction. PLoS One. 2013 Nov 4;8 (11) :e79374.