CCR8 antagonist 1

CCR8 antagonist 1 (Compound 15) is a potente human CCR8 antagonist with a Ki of 1.6 nM. CCR8 antagonist 1 has high safety and metabolic stability. CCR8 antagonist 1 can be used to study diseases such as asthma and multiple sclerosis[1].

Product Specifications

CAS Number

[723304-76-5]

UNSPSC

12352005

Target

CCR

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ccr8-antagonist-1.html

Purity

99.50

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(N1CCC(NS(=O)(C2=C3C=CC=CC3=C(NC(C4=CC=CC=C4C)=O)C=C2)=O)CC1)OCC

Molecular Formula

C26H29N3O5S

Molecular Weight

495.59

References & Citations

[1]Jenkins TJ, et al. Design, synthesis, and evaluation of naphthalene-sulfonamide antagonists of human CCR8. J Med Chem. 2007;50 (3) :566-584.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CCR8

Available Sizes

Curated Selection

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