Linderalactone

Linderalactone is an important sesquiterpene lactone isolated from Lindera aggregata. Linderalactone inhibits cancer growth by modulating the expression of apoptosis-related proteins and inhibition of JAK/STAT signalling pathway. Linderalactone also inhibits the proliferation of the lung cancer A-549 cells with an IC50 of 15 μM[1][2].

Product Specifications

CAS Number

[728-61-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis

Type

Natural Products

Related Pathways

Apoptosis

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/linderalactone.html

Concentration

10mM

Purity

99.96

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

O=C1C2=C[C@@](C3=C(OC=C3C)C/C(C)=C/CC2)([H])O1

Molecular Formula

C15H16O3

Molecular Weight

244.29

Precautions

H302, H315, H319, H335

References & Citations

[1]Deng Y, et al. Linderalactone inhibits human lung cancer growth by modulating the expression of apoptosis-related proteins, G2/M cell cycle arrest and inhibition of JAK/STAT signalling pathway. J BUON. 2019 Mar-Apr;24 (2) :566-571.|[2]Qinghua Sun, et al. Preparative Isolation and Purification of Linderalactone and Lindenenol from Radix linderae by HSCCC. Journal of Liquid Chromatography & Related Technologies. Aug 2005:113-121.