Caspase-3 activator 4
Caspase-3 activator 4 (compound 4o) is a potent and cross the blood-brain barrier caspase-3 activator. Caspase-3 activator 4 shows antiproliferative activity. Caspase-3 activator 4 induces apoptosis. Caspase-3 activator 4 increases the gene expression of TNF-α. Caspase-3 activator 4 decreases the protein expression of cleaved caspases 3/caspases 3[1].
Product Specifications
CAS Number
1817874-62-6
UNSPSC
12352005
Target
Apoptosis; Caspase
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/caspase-3-activator-4.html
Smiles
CC(C(N[C@@H](C(C1=CNC2=C1C=CC=C2)=O)C(NC)=O)=O)(C3=CNC4=C3C=CC=C4)C5=CNC6=C5C=CC=C6
Molecular Formula
C31H27N5O3
Molecular Weight
517.58
References & Citations
[1]Qin X, Xu W, Hu J, Dong Y, Ding R, Huang S, Zhao Z, Chang H, Wang X, Dong S. Structure-activity relationship study of Pseudellone C as anti-glioma agents by targeting TNF/TNFR signaling pathway. Eur J Med Chem. 2024 Aug 26;278:116799.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3
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