PAR4 antagonist 6
PAR4 antagonist 6 (Compound 12) is a PAR4 antagonist, with IC50 values of 134 and 401 nM for hPAR4 (PAC1) and mPAR4 (PAC1), respectively[1].
Product Specifications
UNSPSC
12352005
Target
Protease Activated Receptor (PAR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/par4-antagonist-6.html
Purity
99.35
Solubility
DMSO : 7.14 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CN1N=C(C(NC2=NNC(C3=C(F)C=CC=C3F)=N2)=O)C=C1C4CC4
Molecular Formula
C16H14F2N6O
Molecular Weight
344.32
References & Citations
[1]Smith ST, et al. Discovery of Protease-Activated Receptor 4 (PAR4) -Tethered Ligand Antagonists Using Ultralarge Virtual Screening. ACS Pharmacol Transl Sci. 2024 Mar 21;7 (4) :1086-1100.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PAR4
Available Sizes
Frequently Asked Questions
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