PAR4 antagonist 6

PAR4 antagonist 6 (Compound 12) is a PAR4 antagonist, with IC50 values of 134 and 401 nM for hPAR4 (PAC1) and mPAR4 (PAC1), respectively[1].

Product Specifications

UNSPSC

12352005

Target

Protease Activated Receptor (PAR)

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/par4-antagonist-6.html

Purity

99.35

Solubility

DMSO : 7.14 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CN1N=C(C(NC2=NNC(C3=C(F)C=CC=C3F)=N2)=O)C=C1C4CC4

Molecular Formula

C16H14F2N6O

Molecular Weight

344.32

References & Citations

[1]Smith ST, et al. Discovery of Protease-Activated Receptor 4 (PAR4) -Tethered Ligand Antagonists Using Ultralarge Virtual Screening. ACS Pharmacol Transl Sci. 2024 Mar 21;7 (4) :1086-1100.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PAR4

Available Sizes

Curated Selection

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