Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-Hu CD294 Purified

CD294 (prostaglandin D2 receptor 2) is a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells, but also on eosinophils and basophils. It mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of CD294 gene have been associated with asthma susceptibility. Outside the immune system CD294 is expressed e.g. in gut, heart, and brain. The intracellular C terminal tail contains sites for phosphorylation by protein kinase C.

Product Specifications

Certification

RUO

Immunogen

Human CD294 transfected rat cell line TART/B19-12.10

Target Antigen

CD294

Clone

BM16

Applications

FC (QC tested)

Concentration

1 mg/mL

Format

Purified

Buffer

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*De Fanis U, Mori F, Kurnat RJ, Lee WK, Bova M, Adkinson NF, Casolaro V: GATA3 up-regulation associated with surface expression of CD294/CRTH2: a unique feature of human Th cells. GATA3 up-regulation associated with surface expression of CD294/CRTH2: a unique feature of human Th cells. Blood. 2007 May 15;109 (10) :4343-50. Epub 2007 Jan 18., URL: https://pubmed.ncbi.nlm.nih.gov/17234745/, *Mjösberg J, Bernink J, Golebski K, Karrich JJ, Peters CP, Blom B, te Velde AA, Fokkens WJ, van Drunen CM, Spits H: The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells. Immunity. 2012 Oct 19;37 (4) :649-59., URL: https://pubmed.ncbi.nlm.nih.gov/23063330/, *Bellinghausen I, Reuter S, Martin H, Maxeiner J, Luxemburger U, Türeci Ö, Grabbe S, Taube C, Saloga J: Enhanced production of CCL18 by tolerogenic dendritic cells is associated with inhibition of allergic airway reactivity. J Allergy Clin Immunol. 2012 Dec;130 (6) :1384-93. , URL: http://www.ncbi.nlm.nih.gov/pubmed/23102918 , *Nagata K, Tanaka K, Ogawa K, Kemmotsu K, Imai T, Yoshie O, Abe H, Tada K, Nakamura M, Sugamura K, Takano S: Selective expression of a novel surface molecule by human Th2 cells in vivo. J Immunol. 1999 Feb 1;162 (3) :1278-86., URL: http://www.ncbi.nlm.nih.gov/pubmed/9973380

Storage Conditions

Store at 2-8°C. Do not freeze.

Specificity

The rat monoclonal antibody BM16 recognizes an extracellular epitope of CD294 / CRTH2 (prostaglandin D2 receptor 2), a G-protein-coupled seven-transmembrane protein expressed on Th2 cells, peripheral blood basophils and eosinophils.

Applications Notes

Flow cytometry: Recommended dilution: 1-4 µg/ml.

Species

Human

CAS Number

9007-83-4

Isotype

Rat IgG2a

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

SW1417 Cell Complete Medium
MBS2576676 4x 125 mL

SW1417 Cell Complete Medium

Ask
View Details
GENLISA™ Human IL-1 ELISA
KBH0077 96 Well

GENLISA™ Human IL-1 ELISA

Ask
View Details
Gpr19 (NM_001167694) Mouse Tagged Lenti ORF Clone
MR216739L4 10 µg

Gpr19 (NM_001167694) Mouse Tagged Lenti ORF Clone

Ask
View Details
Human SMPDL3B Protein Lysate
MBS8419877-01 0.02 mg

Human SMPDL3B Protein Lysate

Ask
View Details
Human SMPDL3B Protein Lysate
MBS8419877-02 5x 0.02 mg

Human SMPDL3B Protein Lysate

Ask
View Details