Rabbit anti Human Caspase-7
Product Specifications
Background
Caspase-7 along with caspase 3 and 6 form the group of effector caspases that are responsible for the cleavage of multiple substrates including the cytokeratins, PARP, alpha fodrin, NuMA and others. Caspase-7 occurs in three varient forms.Exalphas rabbit anti-Human caspase-7 antibody reacts with the zymogen and with the 20-23 kDa subunit of caspase-7. Cells should be pretreated with 200 ng/ml of deoxyrubicin for one half hour. Exalphas caspase-7 antibody was generated by immunizing rabbits with the aa 186-198 of Human caspase-7.
CAS Number
9007-83-4
Synonyms
Cysteine-requiring Aspartate Protease-7, Apoptotic protease Mch-3, ICE-like apoptotic protease 3
UniProt
P55210
Host
Rabbit
Species Reactivity
Human
Isotype
IgG
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Field of Research
Apoptosis
Purification Method
Ammonium Sulfate Precipitation
Assay Principle
Applications: western blot, use at 2-10 µg/mL
Stability
See expiration date on vial
Concentration
See vial for Concentration
Form
Provided as solution in phosphate buffered saline with 0,08% sodium azide
Precautions
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.
References & Citations
1. Cohen, G.M., et al. Caspases: the executioners of apoptosis. Biochem. J. 1997, 326, 1-16
2. Chandler, J.M., et al. Different subcellular distribution of Caspase-3 and Caspase-7 following Fas-induced apoptosis in mouse liver. J. Bio. Chem. 1998, 273, 10815-10818
3. Behrensdorf, H.A., et al. The endothelial monocyte-activating polypeptide II (EMAP II) is a substrate for caspase-7. FEBS Lett. 2000, 466, 143-147
Shipping Conditions
Room Temperature
Storage Conditions
Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles
Functional Analysis
WB
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