Sodium 2-mercaptoethanesulfonate
Mesna (Sodium 2-mercaptoethanesulfonate) is an antioxidant which has cytoprotective effects. Mesna is widely used as a systemic protective agent against chemotherapy toxicity. Mesna is also used to reduce hemorrhagic cystitis induced by cyclophosphamide[1][2].
Product Specifications
CAS Number
19767-45-4
Product Name Alternative
Mesnum
UNSPSC
12352211
Hazard Statement
H315, H319, H335
Target
Glutathione Peroxidase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mesna.html
Purity
99.78
Solubility
DMSO : 175 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL
Smiles
SCCS(=O)(O[Na])=O
Molecular Formula
C2H5NaO3S2
Molecular Weight
164.18
Precautions
H315, H319, H335
References & Citations
[1]Yilmaz ER, Kertmen H, Gürer B, The protective effect of 2-mercaptoethane sulfonate (MESNA) against traumatic brain injury in rats. Acta Neurochir (Wien) . 2013 Jan;155 (1) :141-9; discussion 149.|[2]Li X, Yang S, Lv X, The mechanism of mesna in protection from cisplatin-induced ovarian damage in female rats. J Gynecol Oncol. 2013 Apr;24 (2) :177-85.|[3]Gressier B, et, al. Scavenging of reactive oxygen species by letosteine, a molecule with two blocked-SH groups. Comparison with free-SH drugs. Pharm World Sci. 1995 May 26;17 (3) :76-80.|[4]Mesna (2-mercaptoethane sodium sulfonate) functions as a regulator of myeloperoxidase
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
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