Sodium 2-mercaptoethanesulfonate

Mesna (Sodium 2-mercaptoethanesulfonate) is an antioxidant which has cytoprotective effects. Mesna is widely used as a systemic protective agent against chemotherapy toxicity. Mesna is also used to reduce hemorrhagic cystitis induced by cyclophosphamide[1][2].

Product Specifications

CAS Number

[19767-45-4]

Product Name Alternative

Mesnum

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Glutathione Peroxidase

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mesna.html

Purity

99.78

Solubility

DMSO : 175 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL

Smiles

SCCS(=O)(O[Na])=O

Molecular Formula

C2H5NaO3S2

Molecular Weight

164.18

Precautions

H315, H319, H335

References & Citations

[1]Yilmaz ER, Kertmen H, Gürer B, The protective effect of 2-mercaptoethane sulfonate (MESNA) against traumatic brain injury in rats. Acta Neurochir (Wien) . 2013 Jan;155 (1) :141-9; discussion 149.|[2]Li X, Yang S, Lv X, The mechanism of mesna in protection from cisplatin-induced ovarian damage in female rats. J Gynecol Oncol. 2013 Apr;24 (2) :177-85.|[3]Gressier B, et, al. Scavenging of reactive oxygen species by letosteine, a molecule with two blocked-SH groups. Comparison with free-SH drugs. Pharm World Sci. 1995 May 26;17 (3) :76-80.|[4]Mesna (2-mercaptoethane sodium sulfonate) functions as a regulator of myeloperoxidase