Gossypol (acetic acid)
Product Specifications
UNSPSC Description
Gossypol acetic acid ((±)-Gossypol-acetic acid) binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively.
Target Antigen
Bcl-2 Family
Type
Natural Products
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Gossypol-acetic-acid.html
Solubility
DMSO : 25 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL
Smiles
OC1=C(C2=C(O)C(C(C=O)=C(O)C(O)=C3C(C)C)=C3C=C2C)C(C)=CC4=C(C(C)C)C(O)=C(O)C(C=O)=C41.O=C(O)C
Molecular Weight
578.61
References & Citations
[1]Oliver CL, et al. In vitro effects of the BH3 mimetic, (-)-Gossypol, on head and neck squamous cell carcinoma cells. Clin Cancer Res. 2004 Nov 15;10(22):7757-63.Clin Transl Med. 2021 Jun;11(6):e467.|Patent. US20220162561A1.|Cancer Lett. 2019 Oct 1;461:31-43. |Microb Pathog. 2024 Sep 21:106960.|Transbound Emerg Dis. 2023 Nov 11.|Nat Commun. 2023 Jun 10;14(1):3445.|Patent. US20220162561A1.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-17510/Gossypol-acetic-acid-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-17510/Gossypol-acetic-acid-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
12542-36-8
Available Sizes
Curated Selection
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