Gossypol (acetic acid)
Gossypol acetic acid ((±) -Gossypol-acetic acid) binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively.
Product Specifications
CAS Number
[12542-36-8]
Product Name Alternative
(±) -Gossypol-acetic acid; BL-193 (acetic acid)
UNSPSC
12352005
Hazard Statement
H302, H351
Target
Bcl-2 Family
Type
Natural Products
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Gossypol-acetic-acid.html
Concentration
10mM
Purity
99.75
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
OC1=C(C2=C(O)C(C(C=O)=C(O)C(O)=C3C(C)C)=C3C=C2C)C(C)=CC4=C(C(C)C)C(O)=C(O)C(C=O)=C41.O=C(O)C
Molecular Formula
C32H34O10
Molecular Weight
578.61
Precautions
H302, H351
References & Citations
[1]Oliver CL, et al. In vitro effects of the BH3 mimetic, (-) -Gossypol, on head and neck squamous cell carcinoma cells. Clin Cancer Res. 2004 Nov 15;10 (22) :7757-63.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
Bcl-2; Bcl-xL
Citation 01
Cell Rep. 2025 Apr 16;44 (5) :115572.|Clin Transl Med. 2021 Jun;11 (6) :e467.|Patent. US20220162561A1.|Toxicol Sci. 2025 Oct 24:kfaf149.|Microb Pathog. 2024 Sep 21:106960.|Toxics. 2025 Sep 9;13 (9) :763.|Transbound Emerg Dis. 2023 Nov 11:2023:9073566.
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