E235

E235 is an expression regulator of activates transcription factor 4 (ATF4) . E235 reduces cell viability by activating integrated stress response (ISR) and DNA damage response signals. E235 has anti-proliferative activity and can be used for tumor research[1].

Product Specifications

CAS Number

[891894-69-2]

UNSPSC

12352005

Target

Eukaryotic Initiation Factor (eIF)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/e235.html

Purity

99.86

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=CC=C2N3C(SC2=C1)=NC(C4=CC=C(F)C=C4)=C3)NC5CCN(CC6=CC=CC=C6)CC5

Molecular Formula

C28H25FN4OS

Molecular Weight

484.59

References & Citations

[1]Sayers CM, et al. Identification and characterization of a potent activator of p53-independent cellular senescence via a small-molecule screen for modifiers of the integrated stress response. Mol Pharmacol. 2013 Mar;83 (3) :594-604.