LY393615 (free base)
LY393615 (NCC1048) free base is a novel neuronal Ca2+ (calcium channel) and Na + channel (sodium channel) blocker with IC50s of 1.9 μΜ and 5.2 μΜ for α1A and α1B calcium channel subunits. LY393615 free base has good brain penetration and neuroprotective effects in models of in cerebral ischemia that can be used for neurological disease research[1].
Product Specifications
CAS Number
774528-12-0
Product Name Alternative
NCC1048 (free base)
UNSPSC
12352101
Target
Calcium Channel; Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ly393615-free-base.html
Smiles
FC1=CC=C(C2(C3=CC=C(C=C3)F)OC(CC2)CNCCCC)C=C1
Molecular Formula
C21H25F2NO
Molecular Weight
345.43
References & Citations
[1]O'Neill MJ, et.al. LY393615, a novel neuronal Ca (2+) and Na (+) channel blocker with neuroprotective effects in models of in vitro and in vivo cerebral ischemia. Brain Res. 2001 Jan 5;888 (1) :138-149.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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