Src Inhibitor 1
Src Inhibitor 1 is a potent, ATP-competitive and selective dual site Src tyrosine kinase inhibitor with IC50 values of 44 nM for Src and 88nM for Lck.
Product Specifications
CAS Number
179248-59-0
Product Name Alternative
Src Kinase Inhibitor 1; Src-l1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Src
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Src-Inhibitor-1.html
Purity
99.97
Solubility
DMSO : 9.09 mg/mL (ultrasonic)
Smiles
COC1=CC2=NC=NC(NC3=CC=C(OC4=CC=CC=C4)C=C3)=C2C=C1OC
Molecular Formula
C22H19N3O3
Molecular Weight
373.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Tian G, et al. Structural determinants for potent, selective dual site inhibition of human pp60c-src by 4-anilinoquinazolines. Biochemistry. 2001 Jun 19;40 (24) :7084-91.|[2]Bain J, et al. The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408 (3) :297-315.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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