Src Inhibitor 1

Src Inhibitor 1 is a potent, ATP-competitive and selective dual site Src tyrosine kinase inhibitor with IC50 values of 44 nM for Src and 88nM for Lck.

Product Specifications

CAS Number

[179248-59-0]

Product Name Alternative

Src Kinase Inhibitor 1; Src-l1

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Src

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Src-Inhibitor-1.html

Purity

99.97

Solubility

DMSO : 9.09 mg/mL (ultrasonic)

Smiles

COC1=CC2=NC=NC(NC3=CC=C(OC4=CC=CC=C4)C=C3)=C2C=C1OC

Molecular Formula

C22H19N3O3

Molecular Weight

373.40

Precautions

H302, H315, H319, H335

References & Citations

[1]Tian G, et al. Structural determinants for potent, selective dual site inhibition of human pp60c-src by 4-anilinoquinazolines. Biochemistry. 2001 Jun 19;40 (24) :7084-91.|[2]Bain J, et al. The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408 (3) :297-315.