PRMT5-IN-31
PRMT5-IN-31 (Compound 3m) is a selective PRMT5 inhibitor (IC50: 0.31 μM) . PRMT5-IN-31 up-regulates hnRNP E1 protein level. PRMT5-IN-31 occupies the substrate site of PRMT5 and forms essential interactions with amino acid residues. PRMT5-IN-31 has antiproliferative effects against A549 cells by inducing apoptosis and inhibiting cell migration. PRMT5-IN-31 has high metabolic stability on human liver microsomes (T1/2: 132.4 min) [1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Histone Methyltransferase
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/prmt5-in-31.html
Concentration
10mM
Purity
99.25
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O[C@@H](CN1C=CC2=C1C=CC(OC)=C2)CN(C3)CCC4=C3C=CC=C4
Molecular Formula
C21H24N2O2
Molecular Weight
336.43
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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