Silydianin

Silydianin is a flavonolignan. Silydianin can be obtained from Silybum marianum. Silydianin inhibits PTP1B with an IC50 of 17.38 μM. Silydianin inhibits both monophenolase and diphenolase of tyrosinase significantly, with IC50s of 2.6 μM and 16.5 μM, respectively. Silydianin induces Apoptosis and reduces cytokines (IL-4 and IL-5) . Silymarin has antioxidant, cytoprotective and immunomodulatory effects. Silydianin has antitumor activity against prostate cancer. Silymarin can be used in allergic asthma research[1][2][3][4][5][6][7].

Product Specifications

CAS Number

[29782-68-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Endogenous Metabolite; Interleukin Related; Phosphatase; Tyrosinase

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/silydianin.html

Purity

99.79

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1[C@]2([H])C=C([C@@H]3[C@@H](O)C(C4=C(O)C=C(O)C=C4O3)=O)[C@@]5([H])[C@]([C@H]2C6=CC=C(O)C(OC)=C6)([H])CO[C@]51O

Molecular Formula

C25H22O10

Molecular Weight

482.44

Precautions

H302, H315, H319, H335

References & Citations

[1]Vostálová J, et al. Skin Protective Activity of Silymarin and its Flavonolignans. Molecules. 2019 Mar 14;24 (6) .|[2]Qin N, et al. Identification of flavonolignans from Silybum marianum seeds as allosteric protein tyrosine phosphatase 1B inhibitors. J Enzyme Inhib Med Chem. 2018 Dec;33 (1) :1283-1291.|[3]Kim JY, et al. Tyrosinase inhibitory study of flavonolignans from the seeds of Silybum marianum (Milk thistle) . Bioorg Med Chem. 2019 Jun 15;27 (12) :2499-2507.|[4]Zielińska-Przyjemska M, et al. An in vitro study of the protective effect of the flavonoid silydianin against reactive oxygen species. Phytother Res. 2006 Feb;20 (2) :115-9.|[5]Dvorák Z, et al. Primary cultures of human hepatocytes as a tool in cytotoxicity studies: cell protection against model toxins by flavonolignans obtained from Silybum marianum. Toxicol Lett. 2003 Feb 3;137 (3) :201-12.|[6]Davis-Searles PR, et al. Milk thistle and prostate cancer: differential effects of pure flavonolignans from Silybum marianum on antiproliferative end points in human prostate carcinoma cells. Cancer Res. 2005 May 15;65 (10) :4448-57.|[7]Nasab EM, et al. Immunomodulatory effects of two silymarin isomers in a Balb/c mouse model of allergic asthma. Allergol Immunopathol (Madr) . 2020 Nov-Dec;48 (6) :646-653.