K41498 (TFA)

K41498 TFA is a potent and highly selective CRF2 receptor antagonist with Ki values of 0.66 nM, 0.62 nM and 425 nM for human CRF2α, CRF2β and CRF1 receptors respectively. K41498 TFA is an analogues of antisauvagine-30 (aSvg-30), inhibits sauvagine-stimulated cAMP accumulation in hCRF2α- and hCRF2β-expressing cells. K41498 TFA can be used for hypotension study[1].

Product Specifications

UNSPSC

12352209

Target

CFTR

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/k41498-tfa.html

Purity

99.40

Solubility

H2O : 8.33 mg/mL (ultrasonic)

Smiles

[{D-Phe}-HLLRK-{Nle}-IEIEKQEKEKQQAANNRLLLDTI-NH2(TFAsalt)]

Molecular Formula

C162H276N48O46.xC2HF3O2

Molecular Weight

3632.20 (free base)

References & Citations

[1]A Rühmann, et al. Design, synthesis and pharmacological characterization of new highly selective CRF (2) antagonists: development of 123I-K31440 as a potential SPECT ligand. Peptides. 2002 Mar;23 (3) :453-60.|[2]A J Lawrence, et al. The highly selective CRF (2) receptor antagonist K41498 binds to presynaptic CRF (2) receptors in rat brain. Br J Pharmacol