Pheophorbide A

Pheophorbide A is an intermediate product in the chlorophyll degradation pathway. Pheophorbide A can be used as a photosensitizer. Pheophorbide A is a lymphatic vascular activator. Pheophorbide A has antitumor activity. Pheophorbide A can be used for human lymphatic vascular insufficiencies research[1][2][3].

Product Specifications

CAS Number

[15664-29-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis

Type

Natural Products

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/pheophorbide-a.html

Purity

95.0

Solubility

DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C) |Methanol : < 1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C([C@@H]1/C(C(NC(/C=C2C(CC)=C3C)=C4C)=C4C1=O)=C(N=C(/C=C(C(C)=C/5C=C)\NC5=C/C3=N/2)[C@H]6C)\[C@H]6CCC(O)=O)OC

Molecular Formula

C35H36N4O5

Molecular Weight

592.68

Precautions

H302, H315, H319, H335

References & Citations

[1]Jihye Kim, et al. Pheophorbide a identified in an Eupatorium perfoliatum extract is a novel lymphatic vascular activator. Biomed Pharmacother. 2022 Mar;147:112664.|[2]Tang PM, et al. Pheophorbide a, an active compound isolated from Scutellaria barbata, possesses photodynamic activities by inducing apoptosis in human hepatocellular carcinoma. Cancer Biol Ther. 2006 Sep;5 (9) :1111-6.|[3]Ahn MY, et al. Pheophorbide a-mediated photodynamic therapy induces apoptotic cell death in murine oral squamous cell carcinoma in vitro and in vivo. Oncol Rep. 2012 Jun;27 (6) :1772-8.