L-Hyoscyamine (sulfate)

L-Hyoscyamine sulfate (Daturine sulfate), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine sulfate is a levo-isomer to Atropine (HY-B1205) [1][2].

Product Specifications

CAS Number

[620-61-1]

Product Name Alternative

Daturine (sulfate)

UNSPSC

12352005

Hazard Statement

H300+H330

Target

MAChR

Type

Natural Products

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/l-hyoscyamine-sulfate.html

Purity

99.0

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

CN1[C@@H]2C[C@@H](OC([C@@H](C3=CC=CC=C3)CO)=O)C[C@H]1CC2.O=S(O)(O)=O

Molecular Formula

C17H23NO3.1/2H2SO4

Molecular Weight

338.41

Precautions

H300+H330

References & Citations

[1]Lars Göran Axelsson, et al. Regulatory role of 5-HT and muscarinic receptor antagonists on the migrating myoelectric complex in rats. Eur J Pharmacol. 2003 Apr 25;467 (1-3) :211-8.|[2]Harald John, et al. Application of an enantioselective LC-ESI MS/MS procedure to determine R- and S-hyoscyamine following intravenous atropine administration in swine. Drug Test Anal. Mar-Apr 2012;4 (3-4) :194-8.