BI 665915
Product Specifications
UNSPSC Description
BI 665915 is an orally active and potent 5-lipoxygenase-activating protein (FLAP) inhibitor. BI 665915 inhibits FLAP production that blocks LTB4 biosynthesis in mice. BI 665915 is promising for research of various inflammatory diseases, including respiratory and cardiovascular diseases[1].
Target Antigen
FLAP
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/bi-665915.html
Smiles
C[C@@](C1CC1)(C2=CC=C(C3=CN=C(N)N=C3)C=C2)C4=NOC(C5=CN(N=C5)CC(N(C)C)=O)=N4
Molecular Weight
458.52
References & Citations
[1]Takahashi H, et al. Synthesis, SAR, and series evolution of novel oxadiazole-containing 5-lipoxygenase activating protein inhibitors: discovery of 2-[4-(3-{(R)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1, 2, 4] oxadiazol-5-yl)-pyrazol-1-yl]-N, N-dimethyl-acetamide (BI 665915)[J]. Journal of Medicinal Chemistry, 2015, 58(4): 1669-1690.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12995/BI-665915-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12995/
Clinical Information
No Development Reported
CAS Number
1360550-04-4
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