BI 665915

BI 665915, a chemical probe, is an orally active and potent 5-lipoxygenase-activating protein (FLAP) inhibitor. BI 665915 inhibits FLAP production that blocks LTB4 biosynthesis in mice. BI 665915 is promising for research of various inflammatory diseases, including respiratory and cardiovascular diseases[1].

Product Specifications

CAS Number

[1360550-04-4]

UNSPSC

12352005

Target

FLAP

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/bi-665915.html

Smiles

C[C@@](C1CC1)(C2=CC=C(C3=CN=C(N)N=C3)C=C2)C4=NOC(C5=CN(N=C5)CC(N(C)C)=O)=N4

Molecular Formula

C24H26N8O2

Molecular Weight

458.52

References & Citations

[1]Takahashi H, et al. Synthesis, SAR, and series evolution of novel oxadiazole-containing 5-lipoxygenase activating protein inhibitors: discovery of 2-[4- (3-{ (R) -1-[4- (2-amino-pyrimidin-5-yl) -phenyl]-1-cyclopropyl-ethyl}-[1, 2, 4] oxadiazol-5-yl) -pyrazol-1-yl]-N, N-dimethyl-acetamide (BI 665915) [J]. Journal of Medicinal Chemistry, 2015, 58 (4) : 1669-1690.