PROTAC CYP1B1 degrader-1
PROTAC CYP1B1 degrader-1 (Compound 6C), a α-naphthoflavone chimera derivative, is able to eliminate cytochrome P450 (CYP) 1B1-mediated agent resistance via targeted CYP1B1 degradation, with IC50s of 95.1 and 9838.6 nM for CYP1B1 and CYP1A2, respectively. PROTAC CYP1B1 degrader-1 can be used for the research of CYP1B1-overexpressing prostate cancer[1].
Product Specifications
CAS Number
[2411389-67-6]
UNSPSC
12352005
Target
Cytochrome P450; PROTACs
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-cyp1b1-degrader-1.html
Purity
98.09
Solubility
DMF : 10 mg/mL (ultrasonic)
Smiles
COC1=CC=C(C2=C3OC(C4=CC=C(C=C4)C5=CN(N=N5)CCCCCCOC6=CC=CC7=C6C(N(C7=O)C8CCC(NC8=O)=O)=O)=CC(C3=CC(OC)=C12)=O)OC
Molecular Formula
C43H39N5O10
Molecular Weight
785.80
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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