O1918

O1918 is a selective non-CB1 receptor and GPR18 antagonist.

Product Specifications

CAS Number

[536697-79-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Cannabinoid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/O1918.html

Concentration

34.91 mM * 1 mL in Methyl acetate

Purity

98.71

Solubility

10 mM in DMSO

Smiles

C=C([C@@H]1CCC(C)=C[C@H]1C2=C(OC)C=C(C)C=C2OC)C

Molecular Formula

C19H26O2

Molecular Weight

286.41

Precautions

H302, H315, H319, H335

References & Citations

[1]Agnieszka Zakrzeska, et al. A cannabinoid receptor, sensitive to O-1918, is involved in the delayed hypotension induced by anandamide in anaesthetized rats. Br J Pharmacol. 2010 Jun; 160 (3) : 574–584.|[2]Matouk AI, et al. Abnormal cannabidiol confers cardioprotection in diabetic rats independent of glycemic control. Eur J Pharmacol. 2018 Feb 5;820:256-264.