Limonin (Standard)
Product Specifications
UNSPSC Description
Limonin (Standard) is the analytical standard of Limonin. This product is intended for research and analytical applications. Limonin inhibits HIV-1 with an EC50 of 60.0 μM. Limonin induces human colon adenocarcinoma cells apoptosis with an IC50 of 54.74 μM. Limonin has antiviral and antitumor activities[1][2][4].
Target Antigen
Apoptosis; Cytochrome P450; Endogenous Metabolite; HIV; P-glycoprotein
Type
Reference Standards
Related Pathways
Anti-infection;Apoptosis;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/limonin-standard.html
Smiles
O=C1[C@@H]2[C@@]3(O2)[C@](CC[C@@]([C@@]4([C@@](CC(OC4)=O)([H])OC5(C)C)[C@@]5([H])CC6=O)([H])[C@]36C)(C)[C@H](C7=COC=C7)O1
Molecular Weight
470.51
References & Citations
[1]Han YL, Yu HL, Li D, et al. Inhibitory effects of limonin on six human cytochrome P450 enzymes and P-glycoprotein in vitro. Toxicol In Vitro. 2011 Dec;25(8):1828-33.|[2]Kotamballi N. Chidambara Murthy, Jayaprakasha, Vinod Kumar, et al. Citrus Limonin and Its Glucoside Inhibit Colon Adenocarcinoma Cell Proliferation through Apoptosis. J. Agric. Food Chem., 2011, 59 (6):2314-2323.|[3]Mahmoud Zaki El-Readi, Dalia Hamdana, Nawal Farrag, et al. Inhibition of P-glycoprotein activity by limonin and other secondary metabolites from Citrus species in human colon and leukaemia cell lines. European Journal of Pharmacology. 2010,626 (2-3): 139-145.|[4]Battinelli L, Mengoni F, Lichtner M, et al. Effect of limonin and nomilin on HIV-1 replication on infected human mononuclear cells. Planta Med. 2003 Oct;69(10):910-3.|[5]Tanaka T, Kohno H, Tsukio Y, et al. Citrus limonoids obacunone and limonin inhibit azoxymethane-induced colon carcinogenesis in rats. Biofactors. 2000;13(1-4):213-8.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-17411R/Limonin-Standard-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-17411R/
CAS Number
1180-71-8
Available Sizes
Curated Selection
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