Transthyretin-IN-3

Transthyretin-IN-3 (compound 6) is a designed benzofuran analogue. Transthyretin-IN-3 selectively binds to plasma transthyretin (TTR) to inhibit Amyloid aggregation (IC50=5.0±0.2 μM) . Transthyretin-IN-3 can bind to TTR's thyroxine binding site specifically by carrying chlorine substituents at specific locations in its structure. This binding can prevent TTR tetramers from dissociating into unstable monomers[1].

Product Specifications

CAS Number

[3008535-20-1]

UNSPSC

12352005

Target

Transthyretin (TTR)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/transthyretin-in-3.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C(CC)OC2=CC=CC(Cl)=C12)C3=CC(I)=C(O)C(I)=C3

Molecular Formula

C17H11ClI2O3

Molecular Weight

552.53

References & Citations

[1]Mizuguchi, Mineyuki, et al. "Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma." Journal of Medicinal Chemistry (2024) .