Transthyretin-IN-3
Product Specifications
UNSPSC Description
Transthyretin-IN-3 (compound 6) is a designed benzofuran analogue. Transthyretin-IN-3 selectively binds to plasma transthyretin (TTR) to inhibit Amyloid aggregation (IC50=5.0±0.2 μM). Transthyretin-IN-3 can bind to TTR's thyroxine binding site specifically by carrying chlorine substituents at specific locations in its structure. This binding can prevent TTR tetramers from dissociating into unstable monomers[1].
Target Antigen
Transthyretin (TTR)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/transthyretin-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(CC)OC2=CC=CC(Cl)=C12)C3=CC(I)=C(O)C(I)=C3
Molecular Weight
552.53
References & Citations
[1]Mizuguchi, Mineyuki, et al. "Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma." Journal of Medicinal Chemistry (2024).
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-161505/Transthyretin-IN-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-161505/
Clinical Information
No Development Reported
CAS Number
3008535-20-1
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