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PD-1/PD-L1-IN-49

PD-1/PD-L1-IN-49 (compound 1c) is a potent inhibitor of PD-1/PD-L1, with the IC50 of 77 nM. PD-1/PD-L1-IN-49 activates Jurkat T cells, reflecting successful blockade of the PD-1/PD-L1 immune checkpoint[1].

Product Specifications

UNSPSC

12352005

Target

PD-1/PD-L1

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Smiles

CC1=C(C2=CC3=C(C=C2)N(C)CCO3)C=CC=C1NC(C4=NC=C(CNC(CO)(CO)CO)C=C4)=O

Molecular Formula

C27H32N4O5

Molecular Weight

492.57

References & Citations

[1]Julia Zaber, et al. N-methylmorpholine incorporation into the structure of biphenyl leads to the bioactive inhibitor of PD-1/PD-L1 interaction. Bioorg Med Chem Lett. 2024 Jul 10:110:129882.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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