PD-1/PD-L1-IN-49
PD-1/PD-L1-IN-49 (compound 1c) is a potent inhibitor of PD-1/PD-L1, with the IC50 of 77 nM. PD-1/PD-L1-IN-49 activates Jurkat T cells, reflecting successful blockade of the PD-1/PD-L1 immune checkpoint[1].
Product Specifications
UNSPSC
12352005
Target
PD-1/PD-L1
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Smiles
CC1=C(C2=CC3=C(C=C2)N(C)CCO3)C=CC=C1NC(C4=NC=C(CNC(CO)(CO)CO)C=C4)=O
Molecular Formula
C27H32N4O5
Molecular Weight
492.57
References & Citations
[1]Julia Zaber, et al. N-methylmorpholine incorporation into the structure of biphenyl leads to the bioactive inhibitor of PD-1/PD-L1 interaction. Bioorg Med Chem Lett. 2024 Jul 10:110:129882.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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