FFN511

FFN511 is a potent fluorescent false neurotransmitters (FFNs) that targets neuronal vesicular monoamine transporter 2 (VMA T2) . FFN511 inhibits serotonin binding to VMA T2-containing membranes with an IC50 of 1 μM. FFN511 directly images the dynamics of release during exocytosis, can be used to label dopamine terminals in live cortical-striatalacute slices[1][2].

Product Specifications

CAS Number

[1004548-96-2]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Monoamine Transporter

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ffn511.html

Purity

99.40

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C=C(CCN)C2=CC3=C4N(CCC3)CCCC4=C2O1

Molecular Formula

C17H20N2O2

Molecular Weight

284.35

Precautions

H315, H319, H335

References & Citations

[1]Gubernator NG, et al. Fluorescent false neurotransmitters visualize dopamine release from individual presynaptic terminals. Science. 2009 Jun 12;324 (5933) :1441-4.|[2]Keighron JD, et al. Analytical tools to monitor exocytosis: a focus on new fluorescent probes and methods. Analyst. 2012 Apr 21;137 (8) :1755-63.