Tiglic acid

Tiglic acid is a monocarboxylic unsaturated organic acid. Tiglic acid can be isolated from croton oil. Tiglic acid agonizes FFA2 and upregulates PYY expression. Tiglic acid derivatives have anti-inflammatory activity. Tiglic acid can be used in the research of obesity, diabetes, and inflammatory diseases[1][2][3].

Product Specifications

CAS Number

[80-59-1]

UNSPSC

12352211

Hazard Statement

H314

Target

Free Fatty Acid Receptor; Neuropeptide Y Receptor

Type

Natural Products

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tiglic-acid.html

Purity

99.98

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 5 mg/mL (ultrasonic)

Smiles

C/C=C(C)/C(O)=O

Molecular Formula

C5H8O2

Molecular Weight

100.12

Precautions

H314

References & Citations

[1]ROBERT E. BUCKLES, et al. THE PREPARATION OF TIGLIC AND ANGELIC ACIDS AND ESTERS. Cite This:J. Org. Chem.1950153680-684.|[2]Larraufie P, et al. SCFAs strongly stimulate PYY production in human enteroendocrine cells. Sci Rep. 2018 Jan 8;8 (1) :74. |[3]Wang HQ, et al. Hydroxylated Ethacrylic and Tiglic Acid Derivatives from the Stems and Branches of Enkianthus chinensis and Their Potential Anti-inflammatory Activities. J Nat Prod. 2020 Oct 23;83 (10) :2867-2876.