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Heptaminol (hydrochloride)

Heptaminol (RP-2831) hydrochloride is a vasoconstrictor used in the study of hypotension, especially orthostatic hypotension. Heptaminol is also a skin cancer proliferation inhibitor that inhibits immune inflammation induced by the tumor promoting factor 12-O-tetradecanoylphorbol-13-acetate (TPA) in an NO-dependent manner. Heptaminol also acts as a sympathomimetic amine, exerting indirect sympathetic effects. Heptaminol is also an antagonist of catecholamine release and uptake and can increase intracellular free calcium levels[1][2][3].

Product Specifications

CAS Number

543-15-7

Product Name Alternative

RP-2831 hydrochloride

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Heptaminol-hydrochloride.html

Concentration

10mM

Purity

98.0

Solubility

DMSO : ≥ 100 mg/mL|H2O : ≥ 100 mg/mL

Smiles

CC(O)(C)CCCC(N)C.[H]Cl

Molecular Formula

C8H20ClNO

Molecular Weight

181.70

Precautions

H315, H319, H335

References & Citations

[1]Pourrias B, et al. Heptaminol chlorhydrate: new data. Ann Pharm Fr. 1991;49 (3) :127-138.|[2]Reiter M. Die indirekt sympathicomimetische Wirkung von Heptaminol auf den Herzmuskel [Indirect sympathomimetic effect of heptaminol on heart muscle]. Naunyn Schmiedebergs Arch Pharmakol. 1970;267 (2) :114-22. German.|[3]Chung JF, et al. NO-dependent attenuation of TPA-induced immunoinflammatory skin changes in Balb/c mice by pindolol, heptaminol or ATRA, but not by verapamil. Oncotarget. 2016 Jul 26;7 (30) :47576-47585.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Available Sizes

Frequently Asked Questions

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