CYP1B1 ligand 3

CYP1B1 ligand 3 (Compound A1) is a selective inhibitor for cytochrome P450 enzyme CYP1B1 with an IC50 of 11.9 nM. CYP1B1 ligand 3 can be utilized for the synthesis of PROTAC CYP1B1 degrader-2 (HY-158429) [1].

Product Specifications

CAS Number

[65823-65-6]

UNSPSC

12352005

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cyp1b1-ligand-3.html

Purity

99.83

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

ClC1=CC=C(NC2=NC(C3=NC(C4=CC=CC=C4)=CS3)=CS2)C=C1

Molecular Formula

C18H12ClN3S2

Molecular Weight

369.89

References & Citations

[1]Yao X, et al., Development of novel N-aryl-2,4-bithiazole-2-amine-based CYP1B1 degraders for reversing drug resistance. Eur J Med Chem. 2024 Jun 5;272:116488.