Fialuridine

Fialuridine (FIAU), a nucleoside analog, is a HSV-1 and HSV-2 inhibitor with Kis of 0.14 μM and 0.95 μM, respectively. Fialuridine shows anti-orthopoxvirus and anti-hepatitis B virus (HBV) activities. Fialuridine inhibits duck HBV DNA replication with IC50 values of 0.075 μM and 156 μM in human hepatoma cells and in chicken liver cells, respectively[1][2][3].

Product Specifications

CAS Number

[69123-98-4]

Product Name Alternative

FIAU; DRG-0098; NSC 678514

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

DNA/RNA Synthesis; HBV; HSV; Nucleoside Antimetabolite/Analog; Orthopoxvirus

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/fialuridine.html

Purity

99.91

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@H]1[C@H](F)[C@H](N2C(NC(C(I)=C2)=O)=O)O[C@@H]1CO

Molecular Formula

C9H10FIN2O5

Molecular Weight

372.09

Precautions

H302, H315, H319, H335

References & Citations

[1]Mansuri MM, et al. 1- (2-Deoxy-2-fluoro-beta-D-arabinofuranosyl) -5-ethyluracil. A highly selective antiherpes simplex agent. J Med Chem. 1987 May;30 (5) :867-71. |[2]Mark N Prichard, et al. Orthopoxvirus targets for the development of antiviral therapies. Curr Drug Targets Infect Disord. 2005 Mar;5 (1) :17-28. |[3]Staschke KA, et al. The in vitro anti-hepatitis B virus activity of FIAU [1- (2'-deoxy-2'-fluoro-1-beta-D-arabinofuranosyl-5-iodo) uracil] is selective, reversible, and determined, at least in part, by the host cell. Antiviral Res. 1994 Jan;23 (1) :45-61.|[4]Richardson FC, et al. Fialuridine accumulates in DNA of dogs, monkeys, and rats following long-term oral administration. Proc Natl Acad Sci U S A. 1994 Dec 6;91 (25) :12003-7.