Afloqualone

Afloqualone (HQ-495) is an orally active central muscle relaxant and antivertiginous agent that can increase the sensitivity of GABA receptors in neurons of the lateral vestibular nucleus. Afloqualone (HQ-495) can be used in the research of low back pain and neck-arm-shoulder syndrome[1][2][3].

Product Specifications

CAS Number

[56287-74-2]

Product Name Alternative

HQ-495

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Afloqualone.html

Purity

99.94

Solubility

DMSO : 116.67 mg/mL (ultrasonic)

Smiles

O=C1N(C2=CC=CC=C2C)C(CF)=NC3=C1C=C(N)C=C3

Molecular Formula

C16H14FN3O

Molecular Weight

283.30

Precautions

H302, H315, H319, H335

References & Citations

[1]Y Kudo, et al. Effects of afloqualone on vestibular nystagmus and the lateral vestibular nucleus. Jpn J Pharmacol. 1989 Aug;50 (4) :515-9.|[2]A INOUE, et al. Clinical Effect of Afloqualone (HQ-495) on Low Back Pain and Neck-Arm-Shoulder Syndrome By a Double Blind Trial in Comparison with Tolperisone. Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics, 1981, 12 (1) : 137-154.|[3]T Ochiai, et al. Pharmacological studies on 6-amino-2-fluoromethyl-3- (O-tolyl) -4 (3H) -quinazolinone (afloqualone), a new centrally acting muscle relaxant. (II) Effects on the spinal reflex potential and the rigidity. Jpn J Pharmacol. 1982 Jun;32 (3) :427-38.