P53-MDM2-IN-2

P53-MDM2-IN-2 (Compound 5q) is an orally active p53-MDM2 inhibitor with a Ki value of 0.25 μM. p53-MDM2-IN-2 exerts antitumor activity by inhibiting NF-κB pathway[1].

Product Specifications

CAS Number

[1542066-69-2]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

MDM-2/p53; NF-κB

Type

Reference compound

Related Pathways

Apoptosis; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/p53-mdm2-in-2.html

Solubility

10 mM in DMSO

Smiles

O=C1C2=C(C(N1CCCN3C=NC=C3)C4=CC=C(C=C4)Br)C(C5=CC=CC=C5)=NN2CC6=CC=CC=C6

Molecular Formula

C30H26BrN5O

Molecular Weight

552.46

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Zhuang C, et al. Double-edged swords as cancer therapeutics: novel, orally active, small molecules simultaneously inhibit p53-MDM2 interaction and the NF-κB pathway. J Med Chem. 2014 Feb 13;57 (3) :567-77.