(-) -Isocorypalmine

(-) -Isocorypalmine (Tetrahydrocolumbamine), isolated from the crude base fraction of Corydalis chaerophylla, is a dopamine receptor ligand[1]. Recombinant CYP719A21 displays strict substrate specificity and high affinity (Km=4.63 ± 0.71 μM) for (-) -Isocorypalmine[2].

Product Specifications

CAS Number

[483-34-1]

Product Name Alternative

Tetrahydrocolumbamine; (S) -Tetrahydrocolumbamine

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Dopamine Receptor

Type

Natural Products

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/_-_-Isocorypalmine.html

Purity

99.67

Solubility

DMSO : ≥ 6.67 mg/mL

Smiles

OC(C=C1[C@@]2([H])N3CC4=C(C=CC(OC)=C4OC)C2)=C(C=C1CC3)OC

Molecular Formula

C20H23NO4

Molecular Weight

341.40

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Shen XL, et al. Isolation and identification of tetrahydrocolumbamine as a dopamine receptor ligand from Polygala tenuifolia Willd. Yao Xue Xue Bao. 1994;29 (12) :887-890.|[2]Dang TT, et al. Cloning and characterization of canadine synthase involved in noscapine biosynthesis in opium poppy. FEBS Lett. 2014;588 (1) :198-204.