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PP2B-Aα rabbit pAb

Catalytic activity: A phosphoprotein + H (2)O = a protein + phosphate. Cofactor: Binds 1 Fe (3+) ion per subunit. Cofactor: Binds 1 zinc ion per subunit. function: Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates HSPB1 and SSH1. online information: Calcineurin entry, similarity: Belongs to the PPP phosphatase family. similarity: Belongs to the PPP phosphatase family. PP-2B subfamily. subcellular location: Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle. subunit: Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. Interacts with TORC2/CRTC2, MYOZ1, MYOZ2 and MYOZ3.

Product Specifications

Background

Catalytic activity:A phosphoprotein + H (2) O = a protein + phosphate., cofactor:Binds 1 Fe (3+) ion per subunit., cofactor:Binds 1 zinc ion per subunit., function:Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates HSPB1 and SSH1., online information:Calcineurin entry, similarity:Belongs to the PPP phosphatase family., similarity:Belongs to the PPP phosphatase family. PP-2B subfamily., subcellular location:Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle., subunit:Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. Interacts with TORC2/CRTC2, MYOZ1, MYOZ2 and MYOZ3.

Synonyms

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (EC 3.1.3.16;CAM-PRP catalytic subunit;Calmodulin-dependent calcineurin A subunit alpha isoform)

Gene ID

5530

UniProt

Q08209

Cellular Locus

Cytoplasm. Cell membrane ; Peripheral membrane protein. Cell membrane, sarcolemma. Cytoplasm, myofibril, sarcomere, Z line. Cell projection, dendritic spine. Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle (By similarity). Recruited to the cell membrane by scaffold protein AKAP5 following L-type Ca(2+)-channel activation (PubMed:22343722)..

Host

Rabbit

Species Reactivity

Human,Mouse,Rat

Reactivity

Human; Mouse; Rat

Immunogen

Synthesized peptide derived from human PP2B-Aα

Clonality

Polyclonal

Isotype

IgG

Source

Rabbit

Applications

WB, IHC

Validated Applications

WB,IHC

Stability

-20°C/1 year

Concentration

1 mg/mL

Dilution

WB 1:500-2000; IHC-p 1:50-300

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES20264-1.pdf

Subcellular Location

Cytoplasm . Cell membrane ; Peripheral membrane protein . Cell membrane, sarcolemma . Cytoplasm, myofibril, sarcomere, Z line . Cell projection, dendritic spine . Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle (By similarity) . Recruited to the cell membrane by scaffold protein AKAP5 following L-type Ca (2+) -channel activation (PubMed:22343722) . .

Other Product Names

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (EC 3.1.3.16; CAM-PRP catalytic subunit; Calmodulin-dependent calcineurin A subunit alpha isoform)

Gene ID (Human)

5530

SwissProt (Human)

Q08209

Available Sizes

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