PP2B-Aα rabbit pAb

Catalytic activity: A phosphoprotein + H (2)O = a protein + phosphate. Cofactor: Binds 1 Fe (3+) ion per subunit. Cofactor: Binds 1 zinc ion per subunit. function: Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates HSPB1 and SSH1. online information: Calcineurin entry, similarity: Belongs to the PPP phosphatase family. similarity: Belongs to the PPP phosphatase family. PP-2B subfamily. subcellular location: Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle. subunit: Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. Interacts with TORC2/CRTC2, MYOZ1, MYOZ2 and MYOZ3.

Product Specifications

Background

Catalytic activity:A phosphoprotein + H (2) O = a protein + phosphate., cofactor:Binds 1 Fe (3+) ion per subunit., cofactor:Binds 1 zinc ion per subunit., function:Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates HSPB1 and SSH1., online information:Calcineurin entry, similarity:Belongs to the PPP phosphatase family., similarity:Belongs to the PPP phosphatase family. PP-2B subfamily., subcellular location:Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle., subunit:Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. Interacts with TORC2/CRTC2, MYOZ1, MYOZ2 and MYOZ3.

UniProt

Q08209

Swiss Prot

Q08209

Reactivity

Human; Mouse; Rat

Immunogen

Synthesized peptide derived from human PP2B-Aα

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC

Concentration

1 mg/ml

Dilution

WB 1:500-2000; IHC-p 1:50-300

Storage Conditions

-20°C/1 year

Fragment

IgG

Subcellular Location

Cytoplasm . Cell membrane ; Peripheral membrane protein . Cell membrane, sarcolemma . Cytoplasm, myofibril, sarcomere, Z line . Cell projection, dendritic spine . Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle (By similarity) . Recruited to the cell membrane by scaffold protein AKAP5 following L-type Ca (2+) -channel activation (PubMed:22343722) . .

Other Product Names

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (EC 3.1.3.16; CAM-PRP catalytic subunit; Calmodulin-dependent calcineurin A subunit alpha isoform)