Rodatristat
Rodatristat (KAR5417) is a potent tryptophan hydroxylase 1 (TPH1) and TPH2 inhibitor with IC50s value of 33 nM and 7 nM, respectively, and shows robust reduction of intestinal serotonin (5-HT) levels in mice[1].
Product Specifications
CAS Number
[1673568-73-4]
Product Name Alternative
KAR5417
UNSPSC
12352005
Target
5-HT Receptor; Tryptophan Hydroxylase
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/rodatristat.html
Purity
98.41
Solubility
DMSO : 20 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C([C@H]1NCC2(CCN(C3=NC(N)=NC(O[C@H](C4=CC=C(Cl)C=C4C5=CC=CC=C5)C(F)(F)F)=C3)CC2)C1)O
Molecular Formula
C27H27ClF3N5O3
Molecular Weight
561.98
References & Citations
[1]Goldberg DR, et al. Optimization of spirocyclic proline tryptophan hydroxylase-1 inhibitors. Bioorg Med Chem Lett. 2017 Feb 1;27 (3) :413-419.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
MUC4
Available Sizes
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