Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Rodatristat

Product Specifications

Product Name Alternative

KAR5417

UNSPSC Description

Rodatristat (KAR5417) is a potent tryptophan hydroxylase 1 (TPH1) and TPH2 inhibitor with IC50s value of 33 nM and 7 nM, respectively, and shows robust reduction of intestinal serotonin (5-HT) levels in mice[1].

Target Antigen

5-HT Receptor; Tryptophan Hydroxylase

Type

Reference compound

Related Pathways

GPCR/G Protein;Metabolic Enzyme/Protease;Neuronal Signaling

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/rodatristat.html

Purity

99.11

Solubility

DMSO : 20 mg/mL (ultrasonic;warming;heat to 80°C)

Smiles

O=C([C@H]1NCC2(CCN(C3=NC(N)=NC(O[C@H](C4=CC=C(Cl)C=C4C5=CC=CC=C5)C(F)(F)F)=C3)CC2)C1)O

Molecular Weight

561.98

References & Citations

[1]Goldberg DR, et al. Optimization of spirocyclic proline tryptophan hydroxylase-1 inhibitors. Bioorg Med Chem Lett. 2017 Feb 1;27(3):413-419.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-120083/Rodatristat-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-120083/Rodatristat-SDS-MedChemExpress.pdf

Clinical Information

Phase 2

CAS Number

1673568-73-4

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Anti Mouse CD3E Flow Cytometry Monoclonal Clone 1452C11 APC 25ug
IHMAAMSCD3E1452C11CAPC25UG 25 µg

Anti Mouse CD3E Flow Cytometry Monoclonal Clone 1452C11 APC 25ug

Ask
View Details
Human Uncharacterized protein C17orf85, C17orf85 ELISA KIT
ELI-50587h 96 Tests

Human Uncharacterized protein C17orf85, C17orf85 ELISA KIT

Ask
View Details
TSPAN31  polyclonal antibody
BS72098 50 ul

TSPAN31 polyclonal antibody

Ask
View Details
POLD4 (NM_021173) Human Over-expression Lysate
LH11432V 100 µg

POLD4 (NM_021173) Human Over-expression Lysate

Ask
View Details