Rodatristat

Rodatristat (KAR5417) is a potent tryptophan hydroxylase 1 (TPH1) and TPH2 inhibitor with IC50s value of 33 nM and 7 nM, respectively, and shows robust reduction of intestinal serotonin (5-HT) levels in mice[1].

Product Specifications

CAS Number

[1673568-73-4]

Product Name Alternative

KAR5417

UNSPSC

12352005

Target

5-HT Receptor; Tryptophan Hydroxylase

Type

Reference compound

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/rodatristat.html

Purity

98.41

Solubility

DMSO : 20 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

O=C([C@H]1NCC2(CCN(C3=NC(N)=NC(O[C@H](C4=CC=C(Cl)C=C4C5=CC=CC=C5)C(F)(F)F)=C3)CC2)C1)O

Molecular Formula

C27H27ClF3N5O3

Molecular Weight

561.98

References & Citations

[1]Goldberg DR, et al. Optimization of spirocyclic proline tryptophan hydroxylase-1 inhibitors. Bioorg Med Chem Lett. 2017 Feb 1;27 (3) :413-419.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Isoform

MUC4

Available Sizes

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