Thalidomide-5-O-C2-NH2 (hydrochloride)

Thalidomide-5-O-C2-NH2 hydrochloride is the Thalidomide (HY-10984) -based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-5-O-C2-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs[1].

Product Specifications

CAS Number

[2694727-89-2]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/thalidomide-5-o-c2-nh2-hydrochloride.html

Purity

99.55

Solubility

10 mM in DMSO

Smiles

O=C(CCC1N2C(C(C=CC(OCCN)=C3)=C3C2=O)=O)NC1=O.Cl

Molecular Formula

C15H16ClN3O5

Molecular Weight

353.76

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501

References & Citations

[1]Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512 (7512) :49-53. [Content Brief]