Oroxylin A

Oroxylin A is an active flavonoid compound with strong anti-cancer effects. Oroxylin A inhibits the IL-6/STAT3 pathway and NF-κB signaling, inhibits cell proliferation and induces apoptosis. Oroxylin A inhibits colitis-related carcinogenesis[1][2][3][4][5].

Product Specifications

CAS Number

[480-11-5]

Product Name Alternative

Baicalein 6-methyl ether; 6-Methoxybaicalein

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; HIF/HIF Prolyl-Hydroxylase; Virus Protease

Type

Natural Products

Related Pathways

Anti-infection; Autophagy; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Oroxylin-A.html

Purity

99.87

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

O=C1C=C(C2=CC=CC=C2)OC3=CC(O)=C(OC)C(O)=C13

Molecular Formula

C16H12O5

Molecular Weight

284.26

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhao K, et al. Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells. J Hematol Oncol. 2015 Apr 23;8:41. http://www.ncbi.nlm.nih.gov/pubmed/25902914|[2]Dai Q, et al. Oroxylin A regulates glucose metabolism in response to hypoxic stress with the involvement of Hypoxia-inducible factor-1 in human hepatoma HepG2 cells. Mol Carcinog. 2015 Aug 10.|[3]Wei L, et al. Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1α destabilization. Cell Death Dis. 2015 Apr 9|[4]Sun X, et al. Oroxylin A Suppresses the Cell Proliferation, Migration, and EMT via NF-κB Signaling Pathway in Human Breast Cancer Cells. Biomed Res Int. 2019 Jun 23;2019:9241769.|[5]Yang X, et al. Oroxylin A inhibits colitis-associated carcinogenesis through modulating the IL-6/STAT3 signaling pathway. Inflamm Bowel Dis. 2013 Aug;19 (9) :1990-2000.